Replacing Chemotherapy with a Gentler Process: Dr. Danielle Villars, ATLyphe

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How one approaches the goal of replacing chemotherapy with a gentler process? Where does the “we can do it” start? How do you get to the point where your process shows no side effects in the pre-clinical phase, in animals? And when will clinical trials start – in patients?
In this episode, you’ll hear about

• how are blood cells produced
• acute myeloid leukemia
• hematopoietic stem cell transplantation or bone marrow transplant procedure
• how to replace chemotherapy in the conditioning stage

ATLyphe is a Swiss Startup, a spin-off from the ETH Zurich and the University of Zurich. They developed a T cell engager and activator for safer, precise conditioning before hematopoietic stem cell transplantation in leukemia.
My guest today is Dr. Danielle Villars, the CEO of ATLYphe, a biologist who completed her PhD in cancer biology. She already proved she is a high achiever – before committing to science-backed entrepreneurship and bringing this new process to patients, she broke four national records as an Olympic swimmer for Switzerland.
Here’s more about ATLyphe:
https://www.atlyphe.com/
Please note, the treatment is not yet available for patients.
Timestamps:
0:00 Dr. Danielle Villars and ATLyphe
1:18 Aim: No Chemotherapy Side Effects
4:23 How Are Blood Cells Produced
6:28 Gene Mutation in Acute Myeloid Leukemia
11:00 How is Acute Myeloid Leukemia Treated Currently
13:06 What Is the Hematopoietic Stem Cell Transplantation Process
16:06 What is Conditioning before Blood Transplantation
20:40 Immunotherapeutic Approach in Place of Chemotherapy
27:16 What is Graft vs Host Disease
29:27 Beginnings of ALY117 Immunotherapy for Conditioning
37:21 Study Pathway before Patients Can Receive ALY117
45:20 Thank You, Follow ATLyphe
45:48 Follow X-Health.show, Disclaimer
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The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.

Fejezetek

1. Dr. Danielle Villars and ATLyphe (00:00:00)

2. Aim: No Chemotherapy Side Effects (00:01:18)

3. How Are Blood Cells Produced (00:04:23)

4. Gene Mutation in Acute Myeloid Leukemia (00:06:28)

5. How is Acute Myeloid Leukemia Treated Currently (00:11:00)

6. What Is the Hematopoietic Stem Cell Transplantation Process (00:13:06)

7. What is Conditioning before Blood Transplantation (00:16:06)

8. Immunotherapeutic Approach in Place of Chemotherapy (00:20:40)

9. What is Graft vs Host Disease (00:27:16)

10. Beginnings of ALY117 Immunotherapy for Conditioning (00:29:27)

11. Study Pathway before Patients Can Receive ALY117 (00:37:21)

12. Thank You, Follow ATLyphe (00:45:20)

13. Follow X-Health.show, Disclaimer (00:45:48)