Fabio Boi on Corticale’s Ultra-Dense, Minimally Invasive Brain Interfaces

Neural Implant podcast - the people behind Brain-Machine Interface revolutions

In this episode of the Neural Implant Podcast, I speak with Fabio Boi, Co-Founder and CSO of Corticale, an Italian neurotech company that is redefining the landscape of brain-computer interfaces. Corticale is pioneering a new generation of minimally invasive, CMOS-based neural implants that can record from thousands of neurons simultaneously—introducing their flagship technology, SiNAPS.

Fabio walks us through how SiNAPS achieves single-cell resolution recordings via its 1024-electrode array, enabling high-fidelity access to both action potentials and local field potentials deep within cortical tissue. We also explore the significance of modular probe design, ultra high-density sensors, and the potential clinical and research applications of such a breakthrough platform.

This episode is sponsored by Black Swan IP – patent strategy and legal support for neurotech innovators. Learn more at www.blackswan-ip.com/

Top 3 Takeaways:

• Corticale’s SiNAPS probes miniaturize electronics directly beneath each electrode, enabling every channel to independently record signals. Unlike traditional systems that require pre-selection or external r eadout bottlenecks, this design supports simultaneous, high-resolution recording across the entire array.
• Moving from hundreds to thousands of recording channels exposes neural complexity that was previously missed. For brain-computer interfaces, this data richness significantly improves decoding accuracy and performance.
• Startups should prioritize building the right team even before finalizing the technology. As Fabio reflects, having a team with the right expertise early on can help avoid costly mistakes, save time, and steer the company in the right direction—something he wishes he had done from the beginning.

0:45 Do you want to introduce yourself better than I just did?

3:00 What are some of the features of your technology?

5:30 What kind of cutting edge fabrication are you using?

6:30 What application do you see this being useful for?

10:15 Sponsorship by blackswan-ip

10:45 So who are you main customers now?

12:45 What are the upper limits of this technology?

16:00 So you guys are working only on the hardware side of things?

16:45 What kind of data processing do you need for this?

18:45 What do the next 5 years look like for you?

20:15 What kind of patient population would you be targeting?

21:00 What is it like to be based in Italy?

24:00 Is there anything that we didn't talk about that you wanted to mention?