Not Tonight: Brain Circuit for Female Sexual Rejection

Heliox: Where Evidence Meets Empathy

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In this exciting episode, we dive into groundbreaking research that uncovers a fascinating neural circuit in the brain responsible for cyclical female sexual rejection! Join us as we explore the role of progesterone-receptor (PR) expressing neurons in the anterior ventromedial hypothalamus (aVMHvl) and how they influence female sexual behavior.

Discover how these neurons act as gatekeepers during sexual rejection, becoming highly active during behaviors like kicking and boxing but going silent when acceptance is in the air. Co-first author Basma Husain shares insights into how hormonal fluctuations throughout the reproductive cycle impact these neurons, revealing a dual-control system that allows for flexibility in sexual behavior.

We'll discuss the implications of these findings, not just for understanding female sexual dynamics, but also for potential conditions like polycystic ovarian syndrome and the effects of social isolation on behavior. With quotes from leading researchers like Susana Lima and Nicolas Gutierrez-Castellanos, we’ll delve into how the same stimulus can lead to completely different reactions based on a female's internal state.

Tune in for an engaging discussion that highlights the remarkable interplay between hormones, neurons, and behavior, and discover what this research could mean for the future of female sexual health. Don’t miss out on this enlightening journey into the neuroscience of "no"!

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