Manage episode 289107785 series 2851469
Today we’ll be covering Humoral Immunodeficiencies, going along with this month’s theme, Immunology. If you haven’t listened to our podcast before, each week we have a case-based discussion about a medical topic to help you study for the pediatric medicine board exam. Episodes are released every weekend, and the case is then reviewed and reinforced on social media throughout the week.
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A 2 year old male presents to your primary care office for a well child check. He was lost to follow up since his 9 month well child check. The child’s mother would like a referral to ENT because she believes that the child needs to have ear tubes placed due to recurrent ear infections. Upon further questioning, the mother notes that he has had at least six ear infections in the past year. She also reports that he has been treated twice for pneumonia. He has been attending a home daycare since his first birthday. Family history is notable for a maternal uncle who required frequent antibiotics for infections when he was younger, and mom notes that he now frequently receives an “IV medication” to help. She also believes that one of her great uncles passed away from a lung infection when he was a young child. What is the most likely underlying cause of this child’s diagnosis?
- Frequent viral infections
- An accentuation of a physiologic nadir of immunoglobulins
- A block in the development from pre-B cell to mature B cell
- Failure of B cells to terminally differentiate into plasma cells that secrete IgA
- Impaired B cell differentiation with defective immunoglobulin production
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