Dr. Aneil Mallavarapu is leading Humain Ventures, an early stage venture capital firm focused on TechBio. We recorded a conversation together live in San Francisco with an all star audience of friends. At the intersection of biology and AI, there’s something game changing going on and TechBio aims to capture this. Aneil and his partner, 23andMe co-…

Dr. Eric Leuthardt is a top neurosurgeon. Professor at Washington University in St. Louis, he is also one of my favorite inventors. Years ago, we worked together at the Intellectual Ventures Lab on a helical brain surgery tool and origami patches for aneurysms. These days, he is the founder of Aurenar, which has developed a vegus nerve stimulation …

CreateMe is pioneering robots to make clothes. Cam Myers is the founder and in this conversation, we get to pick apart all kinds of things about what they are doing to make this possible. About Cam Cam Myers is CEO and Founder of CreateMe, a company revolutionizing apparel manufacturing through automation and sustainable practices. Cam was born in …

Pablos makes the case for Computational Maximalism. Recorded on April 19, 2025 The post Jensen’s Law appeared first on .Deep Future által

If you are any kind of deep tech founder, or an early stage, deep tech investor, this is a required episode. You need to know about Newlab. It’s one of the most special things in the entire deep tech ecosystem. Scott Cohen is one of the cofounders along with David Bell. They built this thing over the last decade or so in the Navy Yard in Brooklyn p…

Two nerds bullshitting about the cloak and dagger marketplace of raising a venture fund. Recorded on August 16, 2024 The post General Solicitation Rules for VC – ØF appeared first on .Deep Future által

For 2,000 years, there’s been this incredible mystery in material science: how do the Romans build the Pantheon? It’s made of unreinforced concrete, in a seismic zone. After they built it, nobody’s been able to figure out how they did it for two millennia. Until last year when Admir Masic, scientist, professor at MIT showed the world, publishing in…

Two nerds bullshitting about the most important kitchen toy. Recorded on August 16, 2024 The post You Must Buy a Ninja Creami – ØF appeared first on .Deep Future által

Avi Geiger is a super creative roboticist in Seattle, and I got a chance to sit down and pick his brain. He built a company called PicoBrew a little while ago after a career at Microsoft making hardware. PicoBrew was a way for people to do their own brewing at home, he built an entirely automated factory for it. I was always really impressed with t…

Two nerds bullshitting about how to jettison Google. Recorded on August 16, 2024 The post I’m a Perplexity Junkie – ØF appeared first on .Deep Future által

Two nerds bullshitting about electric toys you can ride. Recorded on August 16, 2024 The post Electric Motortoys – ØF appeared first on .Deep Future által

Two nerds bullshitting about the massive leak of social security numbers this week. Recorded on August 16, 2024 The post Mega SSN Leak – ØF appeared first on .Deep Future által

The AESCAPE robot that gave me my first robomassage.  One of the really important things to solve for is how do we get robots working much more closely with humans. And this is really difficult for a whole bunch of reasons, and you guys know some of them. But the truth is they need to be able to really get close. We need them to touch our bodies. A…

Two nerds bullshitting about the imminent scale of computation on Earth. Recorded on July 5, 2024 The post NVIDIA Math – ØF appeared first on .Deep Future által

Two nerds bullshitting about turning your dead relatives into diamonds.. Recorded on July 7, 2024 The post Cremation Diamonds – ØF appeared first on .Deep Future által

One of the awesome guys that got to meet at the Idaho National Labs is Nicholas Woolstenhulme. He’s a mechanical engineer working on the fuel for nuclear reactors, and his whole career has been working on the fuel for nuclear reactors. He gets to learn about all the fuels that are possible to make, test them out, figure out how to make them better,…

Two nerds and an Australian architect bullshitting about turning CAD software into a giant world simulating video game. Recorded on July 5, 2024 The post CAD World Game – ØF appeared first on .Deep Future által

Recently, I got to go hang out at the Idaho National Labs in Idaho Falls. There are thousands of people at those labs, working on the future of energy for the United States. They’re working on renewable energy of course. They’re working on all kinds of things that I had no idea were happening. Around recycling and waste processing, but primarily th…

Two nerds bullshitting about alternatives to college that would provide some of the same benefits. Recorded on July 7, 2024 The post College Experience Alternatives – ØF appeared first on .Deep Future által

Frank Rieger is a hacker in Germany and one of the most well-known spokesman for the chaos computer club. This organization is unlike anything we have in the United States, unlike anything I’ve seen anywhere else in the world. It’s computer hackers who’ve taken an interest in figuring out how to be activists for policy decisions in government that …

Two nerds bullshitting about LinkedIn basically being Dungeons & Dragons for squares. Recorded on July 5, 2024 The post LinkedIn is D＆D – ØF appeared first on .Deep Future által

Two nerds bullshitting about robots that can give a good massage. Recorded on May 15, 2024 The post Massagebot 5000 Part I – ØF appeared first on .Deep Future által

 I got to hang out with Dr. Bruce Damer recently on the beach at Kaplankaya in Turkey. Bruce is an amazing scientist, a humble guy. Who has spent his whole career trying to figure out how did life begin on Earth? He and his co-conspirator Dr. David Deamer have figured out something that not only works as a hypothesis for how life began on Earth – b…

Two nerds bullshitting about making amino acid Legos that kids can plug together to make proteins. This turned into a completely unrelated conversation about delivering personalized pharmaceuticals. Recorded on May 15, 2024 The post Amino Acid Anal Bead Toy for Kids – ØF appeared first on .Deep Future által

 Robert Green is a professor of genetics at Harvard Medical School. He’s the director of Genetics Research at Brigham and Women’s hospital and the co-founder of Nurture Genomics, where they’re doing genomic screening for infants to detect and mitigate actionable genetic conditions. If you don’t understand what that means, you’re in the right place …

Two nerds bullshitting about feeding the output from one industrial process as the input for another. Recorded on May 15, 2024 The post Industrial Ouroboros – ØF appeared first on .Deep Future által

Dan Shapiro with his game Robot Turtles. Photo by Jonathan H. Liu I met Dan Shapiro years ago when I went out to fly kites with Elan Lee. What a delightful guy! Dan is an inspiring entrepreneur with boundless energy, always upbeat. He’s had, I think, four companies that succeeded, maybe three that were venture backed. Dan did something super cool. …

Two nerds bullshitting about using X-PRIZE and Kickstarter to get nuclear reactors built. Recorded on May 15, 2024 The post Nuclear Reactor Kickstarter – ØF appeared first on .Deep Future által

Two nerds bullshitting about their search for the ultimate black t-shirt. We tried shirts from Vollebak, Ministry of Supply, ETON, Wyr. Recorded on March 13, 2024 The post Black T-Shirt Review – ØF appeared first on .Deep Future által

Paris, 1987. Rob Angel, during the game’s launch in France  Rob Angel is the inventor of Pictionary. You have played this game. I don’t know anyone who hasn’t. He Invented the game in 1985 and started manufacturing it in his studio apartment in Seattle, and then literally went out onto the streets, trying to sell it to people face to face. Since th…

Two nerds bullshitting about a decentralized YouTube. Recorded on March 13, 2024 The post YouTube of Alexandria – ØF appeared first on .Deep Future által

Two nerds bullshitting about adapting cybersecurity to LLMs. Pablos: I have a totally different angle here. The topic is cybersecurity for AI so right now people are definitely doing cybersecurity to keep their models proprietary and keep their weights to themselves and this kind of thing. That’s not what I’m talking about. Cybersecurity for AIs is…

Garrett Lisi by Martin Schoeller  I’ve got a real soft spot for heretics and people who carve their own path outside of the institutions and societal norms and things that everyone is so pressured into because it creates this echo chamber and there’s these cookie cutter outcomes, it’s not conducive to getting to new ideas, it’s not good for figurin…

Two nerds bullshitting about E-ink T-Shirts. Recorded on March 13, 2024 The post E-ink Everywhere – ØF appeared first on .Deep Future által

Rob Shepherd by Matthew Palumbo I’ve gotten to spend a little bit of time with Rob Shepherd over the years. He’s working on soft robotics and all the different kinds of materials advancements that could really help us make robots that are more naturally integrated into the world. Things like polymer colloidal suspensions as inks for 3d printers so …

Two nerds bullshitting about augmented reality tattoos. Pablos: I don’t know if this exists, but AR tattoos should totally be a thing. and this is just I think there’s a couple different embodiments for this, but basically there should just be an app where you aim it at anybody and they can set their own tattoos on, right? So like if I hold up my p…

Lee Cronin by Business Wire  Lee Cronin is a true mad scientist. He’s a professor of chemistry in Glasgow, where he also founded Chemify. This is a company that has invented a new type of approach to accomplish chemistry, very analogous to using the tool chain that we use in computers and then adapting that to chemistry. I think this analogy holds …

Two nerds bullshitting about an augmented reality baseball cap. Pablos: With AR, I think we got it wrong. Everybody’s been trying to put dragons in the room or have a whale in the room or whatever. And they’re going for this super realistic, photorealistic, immersive experience. And I think the only thing that really matters is dashboards. And even…

Two nerds bullshitting about being able to annotate everything. Recorded on March 13, 2024 The post Mother of all Annotators – ØF appeared first on .Deep Future által

 If you ever get the chance to hang out with David Eagleman, first of all do it. The first thing you’re going to notice is that he’s extremely nice, fun, outgoing and very friendly. He’s lit up in the brain and he’s prolific, he’s doing a zillion different things and he’s still somehow nice enough to hang out and listen and chat. Davis is a neurosc…

Two nerds bullshitting about a worldwide bug tracker. Recorded on March 13, 2024 The post Mother of all Bug Trackers – ØF appeared first on .Deep Future által

Music producer & sound engineer John Vitale is creating music to help people optimize brain states. After co- founding Focus@Will, where he designed music and soundscape channels for flow state he moved on to found Brain Music Labs Where he’s crafting new ways to use entrainment based music and media for reducing stress, anxiety, and cravings with …

Two nerds bullshitting about robots getting some of mammals’ greatest hits. Recorded on February 4, 2024 The post Fingers for Robots – ØF appeared first on .Deep Future által

A true polymath, Moran started out in the Israeli military, in one of their elite intelligence units. Then ended up working as a hacker in computer security. And to this day is still in demand for that, but he had a weird experience when Francis Crick told him to junk hacking and get into working on neuroscience, and he did. And so Moran’s had this…

Two nerds bullshitting about stunts on the internet.  Another idea I had a long time ago. That, unfortunately never deployed widely. I prototyped in the late nineties, it was called the Internet Random Mail Reader. For people who don’t know the way networks work is like your computer is just broadcasting all the packets out on the network and all t…

Riley Knox is an entrepreneur that I met when I was hanging out in Austin, Texas, and I was just truly impressed with him, his energy, his outlook, his technical approach to building these companies that are hard. He had this company called Accelerate3D that he built to advance 3D printing for manufacturing, make it fast enough and cheap enough tha…

Two nerds bullshitting about possible robots. The Lashbot5000 is a concept for adapting a surgical robot to install lash extensions. Apparently this has now been accomplished by LUUM in Oakland. You can see their robot in action here: Then we eventually get around to describing the totally genius but as of yet unbuilt Miyagibot which can find flies…

Years ago, I got to be an advisor for this company called data.world, and at the time, they were just getting started on helping figuring out how do you converge all the data sets that are in the world and help people work with them and combine them and share them. They built this thing that was kind of like GitHub for data. I was interested in it …

One of the things that’s on the verge of excitement and annoyance for me is the way that Artificial Intelligence work has all kind of converged around deep learning. Deep learning is amazing and super powerful, and we’ve gotten a lot out of it, but what it has done is, both attracted a lot of people to Artificial Intelligence, but also, steered all…

Short episode where Ash & Pablos marvel at this ingenious invention called the GyroGlove that can ameliorate the jittery hands of folks with Parkinson’s disease. If anyone can introduce us to the inventor, Dr. Faii Ong, we want to get him on the podcast! Recorded on February 4, 2024 The post GyroGlove – ØF appeared first on .…