#14: The Exposome Exposed: Environmental Factors, Women’s Autoimmune Issues, and Digital Twins with Dr. Fady Shmouni

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The Invisible Factors Impacting Women’s Health: A Deep Dive with Dr Fady Shmouni

In this episode, we sit down with Dr Fady Shmouni, a physician-scientist trained in endocrinology, internal medicine, and genetics, to explore the often-overlooked, invisible factors affecting women’s health at a cellular level.

Dr Shmouni introduces the concept of the exposome—the full range of environmental exposures that influence our biology—and how these shape women’s long-term wellbeing. We explore the surge in autoimmune conditions, the roles that digital twins and multi-omics may play in female longevity, and practical ways to mitigate everyday environmental toxins such as microplastics, endocrine disruptors, and light pollution.

He also shares insights into hormonal imbalances, the emerging world of peptides, and the potential of digital twin technology to redefine personalised medicine.

Timestamps
00:00 Introduction to Dr Fady Shmouni and Personalised Health
00:51 Understanding the Exposome
03:10 Impact of Food and Home Environment on Health
07:37 Lighting and Its Effects on Health
15:52 Measuring and Mitigating Exposome Risks
27:29 Makeup and Cosmetics: Hidden Health Risks
37:37 Autoimmune Disorders in Women
40:34 Epigenetics and Exposome Interaction
44:03 Understanding Exposomes and Genetic Susceptibility
46:04 Early Signs of Autoimmune Disorders in Women
48:09 Hormonal Influence on the Immune System
51:11 Exploring Peptides and Their Benefits
01:01:25 The Future of Medicine: Digital Twins and Multi-Omics
01:14:41 Practical Advice for Women’s Health and Longevity
01:18:02 Closing Thoughts and Curveball Questions

📚 Resources Mentioned in This Episode

1. 🌍 The Exposome & Environmental Health
   
   • Exposome Moonshot Initiative (Washington D.C.) – a global collaboration defining and researching environmental exposures and their impact on long-term health.
     
   • Government Environmental Databases – lists such as the US “Dirty Dozen” and Clean 15 foods for minimizing pesticide exposure.
     
   • Key Topics Covered: microplastics, endocrine-disrupting chemicals, circadian lighting, indoor air pollution, cosmetics toxicity, and heavy-metal exposure.
     
2. 🔬 Testing & Monitoring Tools
   
   • Ellie Health – Cortisol Test Strips
     Home saliva testing for cortisol and circadian rhythm health.
     (brand mentioned by Fady)
     
     
   • Environmental Toxin Tests
     
     • Heavy metal analysis (mercury, lead, cadmium).
       
     • Mycotoxin testing for fungal toxins.
       
     • Microplastic & PFAS testing (dry blood or urine samples).
       
   • Air Quality Tools
     
     • CO₂ Monitors and home air sensors (Fady recommends using affordable Amazon devices).
       
     • Dyson Air Purifier – combines purification and CO₂ tracking.
       
3. 💡 Wellness & Longevity Technologies
   
   • Digital Twin Medicine – personalized, data-driven replicas of a patient’s biology using multi-omics (genomics, epigenomics, microbiome, exposome, wearable data).
     
   • Wearables – Apple Health, smart mirrors, sleep sensors, and circadian lighting systems.
     
   • Therapeutic Plasma Exchange (TPE) – advanced clinical detoxification method discussed for toxin removal and biological-age reduction.
     
   • Peptide Therapies – including BPC-157, TB-500, copper peptides, and GLP-1 analogs for recovery, regeneration, and longevity.
     

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